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1

Treatment of nausea and vomiting: Gaps in our knowledge

Gareth J. Sanger, Paul L.R. Andrews

Journal:

Autonomic Neuroscience

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

2

5-Hydroxytryptamine and the gastrointestinal tract: where next?

Gareth J. Sanger

Journal:

Trends in Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 414 KB

english, 2008

3

Dorsal root ganglion neurons show increased expression of the calcium channel α2δ-1 subunit following partial sciatic nerve injury

Richard A Newton, Sharon Bingham, Patrick C Case, Gareth J Sanger, Sally N Lawson

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 864 KB

english, 2001

4

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

Sanger, Gareth J., Furness, John B.

Journal:

Nature Reviews Gastroenterology and Hepatology (formerly Nature Clinical Practice Gastroenterology and Hepatology)

Year:

2015

Language:

english

File:

PDF, 458 KB

english, 2015

5

The Benefits of Olanzapine in Palliating Symptoms

Davis, Mellar P., Sanger, Gareth J.

Journal:

Current Treatment Options in Oncology

Year:

2021

File:

PDF, 440 KB

2021

6

Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation

Jason Witherington, Lee Abberley, Michael A. Briggs, Katharine Collis, David K. Dean, Alessandra Gaiba, N. Paul King, Helmut Kraus, Nicola Shuker, Jon G.A. Steadman, Andrew K. Takle, Gareth Sanger, Gr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 117 KB

english, 2008

7

Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor

Jason Witherington, Lee Abberley, Benjamin R. Bellenie, Rio Boatman, Katharine Collis, David K. Dean, Alessandra Gaiba, N. Paul King, Nicola Shuker, Jon G.A. Steadman, Andrew K. Takle, Gareth Sanger,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 149 KB

english, 2009

8

Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266

Michael Fedouloff, Frank Hossner, Martyn Voyle, Jennie Ranson, Jenifer Powles, Graham Riley, Gareth Sanger

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 243 KB

english, 2001

9

Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders

Sanger, Gareth J., Lee, Kevin

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

10

Pharmacological characterization of the vanilloid receptor in the rat dorsal spinal cord

Kay A Wardle, Jennie Ranson, Gareth J Sanger

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 307 KB

english, 1997

11

Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats

Kate E Read, Gareth J Sanger, Andrew G Ramage

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 231 KB

english, 2003

12

Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain

Gareth J Sanger

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 243 KB

english, 2004

13

Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat

Yasutake Shimizu, Ed C. Chang, Anthony D. Shafton, Dorota M. Ferens, Gareth J. Sanger, Jason Witherington, John B. Furness

Journal:

The Journal of Physiology

Year:

2006

Language:

english

File:

PDF, 433 KB

english, 2006

14

5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives

Bermudez, Jose, Fake, Charles S., Joiner, Graham F., Joiner, Karen A., King, Frank D., Miner, Wesley D., Sanger, Gareth J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 807 KB

english, 1990

15

Substituted benzamides with conformationally restricted side chains. 5. Azabicyclo[x.y.z] derivatives as 5-HT4 receptor agonists and gastric motility stimulants

King, Frank D., Hadley, Michael S., Joiner, Karen T., Martin, Roger T., Sanger, Gareth J., Smith, Duncan M., Smith, Gillian E., Smith, Paul, Turner, David H., Watts, Eric A.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 971 KB

english, 1993

16

Prokineticin-2, motilin, ghrelin and metoclopramide: Prokinetic utility in mouse stomach and colon

Anna K. Bassil, Narinder B. Dass, Charles D. Murray, Alison Muir, Gareth J. Sanger

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

17

The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones

Anna K. Bassil, Narinder B. Dass, Gareth J. Sanger

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 271 KB

english, 2006

18

Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats

Nasser M. Malik, Yong-Ling Liu, Nicholas Cole, Gareth J. Sanger, Paul L.R. Andrews

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 482 KB

english, 2007

19

Defensive and pathological functions of the gastrointestinal NK3 receptor

Gareth J. Sanger, Bishwa R. Tuladhar, Lionel Bueno, John B. Furness

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

20

Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin

Catharina Olsson, Joanna D. Holbrook, Giulia Bompadre, Elisabeth Jönsson, Charles H.V. Hoyle, Gareth J. Sanger, Susanne Holmgren, Paul L.R. Andrews

Journal:

General and Comparative Endocrinology

Year:

2008

Language:

english

File:

PDF, 1.72 MB

english, 2008

21

5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat

Charlie Reavill, Jon P. Hatcher, V.Ann Lewis, Gareth J. Sanger, Jim Hagan

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 555 KB

english, 1998

22

Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations

Gareth J Sanger, Elizabeth S Ellis, Mark H Harries, Nick S Tilford, Kay A Wardle, Christopher D Benham

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

23

Thermal, But Not Mechanical, Nociceptive Behavior is Altered in the Zucker Diabetic Fatty Rat and Is Independent of Glycemic Status

Valerie Piercy, Stephen E Banner, Amit Bhattacharyya, Andrew A Parsons, Gareth J Sanger, Stephen A Smith, Sharon Bingham

Journal:

Journal of Diabetes and its Complications

Year:

1999

Language:

english

File:

PDF, 211 KB

english, 1999

24

A prostaglandin analogue which potently relaxes human uterus but not gut muscle

Gareth J. Sanger, Anne Jackson, Alan Bennett

Journal:

European Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 209 KB

english, 1982

25

The effects of various pharmacological agents on the metoclopramide-induced increase in cholinergic-mediated contractions of rat isolated forestomach

Gareth J. Sanger

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 538 KB

english, 1985

26

Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat

Gareth J. Sanger, Christine M. McClelland

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 574 KB

english, 1986

27

Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron)

Gareth J. Sanger, David R. Nelson

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 902 KB

english, 1989

28

Increased defaecation caused by 5-HT4 receptor activation in the mouse

Stephen E. Banner, Martin I. Smith, Darren Bywater, Laramie M. Gaster, Gareth J. Sanger

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 628 KB

english, 1996

29

Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret

Andrew G. King, Gareth J. Sanger

Journal:

Neuroscience Letters

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

30

Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin

John A. Rudd, Man P. Ngan, Man K. Wai, Andrew G. King, Jason Witherington, Paul L.R. Andrews, Gareth J. Sanger

Journal:

Neuroscience Letters

Year:

2006

Language:

english

File:

PDF, 126 KB

english, 2006

31

Pica—A model of nausea? Species differences in response to cisplatin

Yong-Ling Liu, Nasser Malik, Gareth J. Sanger, Mark I. Friedman, Paul L.R. Andrews

Journal:

Physiology & Behavior

Year:

2005

Language:

english

File:

PDF, 212 KB

english, 2005

32

The translational value of rodent gastrointestinal functions: a cautionary tale

Gareth J. Sanger, Joanna D. Holbrook, Paul L.R. Andrews

Journal:

Trends in Pharmacological Sciences

Year:

2011

Language:

english

File:

PDF, 3.45 MB

english, 2011

33

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR

Andrew D. Medhurst, Frank Lezoualc’h, Rodolphe Fischmeister, Derek N. Middlemiss, Gareth J. Sanger,

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 878 KB

english, 2001

34

Drugs targeting functional bowel disorders: insights from animal studies

Gareth J Sanger, Gareth A Hicks

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

35

Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets

John B Furness, Gareth J Sanger

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 141 KB

english, 2002

36

Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction

Paul L.R Andrews, Gareth J Sanger

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

37

Gastrointestinal neuropharmacology: identification of therapeutic targets

John B. Furness, Gareth J. Sanger

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 36 KB

english, 2002

38

PINANE THROMBOXANE A2 ANALOGUES ARE NON-SELECTIVE PROSTANOID ANTAGONISTS IN RAT AND HUMAN STOMACH MUSCLE

ALAN BENNETT, GARETH J. SANGER

Journal:

British Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 702 KB

english, 1982

39

Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism

Wesley D. Miner, Gareth J. Sanger

Journal:

British Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 317 KB

english, 1986

40

The effects of granisetron, ICS 205–930 and ondansetron on the visceral pain reflex induced by duodenal distension

Helen E. Moss, Gareth J. Sanger

Journal:

British Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 921 KB

english, 1990

41

The guinea-pig distal colon - a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions

Kay A. Wardle, Gareth J. Sanger

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.27 MB

english, 1993

42

Pharmacological Characterization of the Vanilloid Receptor in the Rat Isolated Vas Deferens

KAY A. WARDLE, GENEVIVE FUREY, GARETH J. SANGER

Journal:

Journal of Pharmacy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 620 KB

english, 1996

43

Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases

Gareth J. Sanger

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 260 KB

english, 2008

44

The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression

Dominic-Luc Webb, Tobias Rudholm-Feldreich, Linda Gillberg, Md. Abdul Halim, Elvar Theodorsson, Gareth J. Sanger, Colin A. Campbell, Malcolm Boyce, Erik Näslund, Per M. Hellström

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2013

Language:

english

File:

PDF, 417 KB

english, 2013

45

Motilin receptor neuropharmacology: revised understanding

Sanger, Gareth J

Journal:

Current Opinion in Pharmacology

Year:

2012

Language:

english

File:

PDF, 262 KB

english, 2012

46

New target profiling for gastrointestinal disorders: where are we going?

Sanger, Gareth J

Journal:

Current Opinion in Pharmacology

Year:

2012

Language:

english

File:

PDF, 139 KB

english, 2012

47

Novel approaches and clinical opportunity for gastrointestinal prokinetic drugs

Richard A. Borman, Gareth J. Sanger

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2007

Language:

english

File:

PDF, 118 KB

english, 2007

48

Gastrointestinal diseases

Gareth J. Sanger

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2007

Language:

english

File:

PDF, 83 KB

english, 2007

49

Inhibition by tianeptine of neuronally mediated contractions in the rat isolated gastrointestinal tract

Victoria N. Bolton, Anna K. Bassil, Kevin Lee, Gareth J. Sanger

Journal:

Pharmacological Research

Year:

2008

Language:

english

File:

PDF, 457 KB

english, 2008

50

Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon

Emma M. Jarvie, Selim Cellek, Gareth J. Sanger

Journal:

Pharmacological Research

Year:

2008

Language:

english

File:

PDF, 573 KB

english, 2008